Compared with the CG, the IG had shorter length of hospital stay, better recovery of gastrointestinal function, better improvements of nutritional indicators such as ALB and PAB, lower levels of pro-inflammatory factors TNF-α, IL-6 and CRP, better improvement of CD4+/CD8+ ratio, lower incidence of postoperative complications, lower SAS and SDS scores and better quality of life. The gene discussed is TNF; the disease is SATB2 associated disorder.