SPARC and colon adenocarcinoma: SPARC was highly expressed in 15 tumor cell lines, such as ACC, BRCA, colon adenocarcinoma (COAD), DLBC, ESCA, GBM, HNSC, kidney renal clear cell carcinoma (KIRC), brain lower-grade glioma (LGG), LIHC, PAAD, rectum adenocarcinoma (READ), SKCM, STAD, and THYM, and was expressed at a low level in UCEC (Figure 8A).