Han et al. reported that RNA polymerase mitochondrial (POLRMT), essential for mtRNA transcription, is significantly upregulated in osteosarcoma, and its inhibition impairs mtRNA synthesis, mitochondrial function, and tumor growth (Huan et al., 2024; Han et al., 2021; Yu et al., 2021; Li et al., 2023; Kong et al., 2024). The gene discussed is POLRMT; the disease is neoplasm.