Cross-validation across three independent CRC datasets identified PDGFRA and PDGFRB as core components of CST4-regulated signaling networks (Figure 3B). Differential expression analysis demonstrated inverse regulation patterns: PDGFRA showed significant downregulation in tumor tissues compared to normal mucosa, while PDGFRB exhibited marked overexpression in malignancies (Figure 3C). Here, CST4 is linked to neoplasm.