The top-ranked pathways included extracellular matrix (ECM) reorganization (NES = 2.12, FDR q<0.001), focal adhesion signaling (NES = 1.98, FDR q=0.004), and cancer-related pathway activation (NES = 1.85, FDR q=0.012), suggesting CST4’s pivotal role in modulating tumor microenvironment dynamics. This evidence concerns the gene CST4 and cancer.