Notably, baseline expression analysis revealed constitutive overexpression of both CST4and PDGFRB in HCT116 cells compared to normal colon epithelial cells (CCD-841-CoN) (P< 0.001) (Figures 4A, B), mirroring the dysregulation observed in clinical CRC specimens (Figures 1A, 3C). This evidence concerns the gene PDGFRB and colorectal carcinoma.