Finally, we assessed the diagnostic performance of TFF2 alongside conventional tumor markers, including CEA (CEACAM5) and CA125 (MUC16), for PanIN and PC through ROC curve analysis, and the AUC values were 1.000 and 0.904, significantly outperforming other tumor markers (Figure 3F). The gene discussed is MUC16; the disease is pachyonychia congenita.