As OSMR is expressed by these cells (5, 22, 23) as well as some mucosal and glandular epithelial cells (42), OSMR and OSM may also play important roles in several non-hematological malignancies by directly acting on tumor cells or indirectly via endothelial and mesenchymal cells such as fibroblasts in the tumor environment. This evidence concerns the gene OSMR and hematologic disorder.