PSMA7 and anemia (phenotype): Indeed, Osmr-/- mice display mild anemia and thrombocytopenia (21–23) with decreased HSPC cycling in the bone marrow, increased HSPC chemotactic response, increased HSPC mobilization into the blood in response to G-CSF or CXCR4 antagonists, as well as decreased expression of genes associated with cell cycling, lipid metabolism, and erythropoiesis in hematopoietic stem cells (HSC) (5).