Kaplan-Meier plots in Figures 1, 2 and previous reports discussed above clearly indicate that the interaction of OSM with the OSMR: GP130 receptor complex plays a role in the pathobiology and response to treatment of a number of malignancies such as AML, MPNs, glioma and glioblastoma, pancreatic, gastric and renal carcinomas where high expression of OSMR or OSM transcripts has poor prognosis value. The gene discussed is OSM; the disease is central nervous system cancer.