3) In a mouse model of lymphoproliferative neoplasm driven by activating mutation of the FLT3 tyrosine kinase domain (FLT3-TKD), co-transduction with OSM cDNA switched the lymphoproliferative FLT3-TKD neoplasm to a myeloproliferative neoplasm suggesting that OSM is a potent inducer of a pro-myeloid niche (35). Here, FLT3 is linked to myeloproliferative disorder.