Indeed, Osmr-/- mice display mild anemia and thrombocytopenia (21–23) with decreased HSPC cycling in the bone marrow, increased HSPC chemotactic response, increased HSPC mobilization into the blood in response to G-CSF or CXCR4 antagonists, as well as decreased expression of genes associated with cell cycling, lipid metabolism, and erythropoiesis in hematopoietic stem cells (HSC) (5). This evidence concerns the gene PSMA7 and anemia.