Univariate Cox regression analysis indicated that the autophagy risk score, age, albumin, β2-microglobulin (β2M), lactate dehydrogenase (LDH), International Staging System (ISS), and Revised International Staging System (R-ISS) were associated with overall survival (OS) in multiple myeloma (MM) patients. This evidence concerns the gene B2M and plasma cell myeloma.