NET-associated Cathepsin G (CTSG) then entered CRC cells through the receptor for advanced glycation end products (RAGE) on the cell membrane, leading to the cleavage of 14–3-3ε proteins, releasing Bcl-2-associated X protein (Bax) to mitochondria, and triggering apoptosis in CRC cells15. Here, CTSG is linked to colorectal carcinoma.