However, the molecular drivers of CADOSA comorbidity are still poorly understood, despite the fact that shared genetic locus genes, such as CDKN2B-AS1, PHACTR1, CELSR2, LPA, CARMAL, MFGE8, and GGT5, have been implicated in both CAD and OSA (24). The gene discussed is CARMAL; the disease is obstructive sleep apnea syndrome.