One study analysing data from 1194 adults with T1D using connected insulin pens and CGM reported a significant increase in TBR <70 mg/dL (<3.9 mmol/L) with increasing bolus frequency,18 as well as significantly increased TIR 70–180 mg/dL (3.9–10.0 mmol/L) and reduced glycaemic variability. This evidence concerns the gene INS and type 1 diabetes mellitus.