In this context, we found that treatment of microglial cells with GBM‐derived supermeres led to a marked reduction in anti‐inflammatory cytokine production—most notably IL‐4 and TGFβ1—mimicking the effects observed with lipopolysaccharide (LPS), a prototypical TLR4 ligand. The gene discussed is TLR4; the disease is glioblastoma.