Additionally, fasting serum insulin levels were reduced following hADP‐Ucp1 OE plasmid treatment (Figure 5N), and the homeostasis model assessment of insulin resistance (HOMA‐IR) index (a widely used mathematical index to estimate insulin resistance (IR)) showed a significant improvement in hADP‐Ucp1 OE plasmid‐treated mice (Figure 5O). This evidence concerns the gene UCP1 and Insulin resistance.