UCP1 and fatty liver disease: However, the indicators of liver injury, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), significantly decreased in hADP‐Ucp1 OE plasmid‐treated mice (Figure 7O and P), suggesting that the hADP‐Ucp1 OE plasmid treatment improved the liver injury caused by HFD‐induced hepatic steatosis.