To investigate this, we induced atherosclerosis in Ldlr–/– mice stably reconstituted with bone marrow from CD4Cre+/Prdm1flox/flox (Prdm1−/−) or Prdm1flox/flox (Prdm1+/+) mice and fed them a high-fat diet for 12 weeks. Here, PRDM1 is linked to atherosclerosis.