The association of PRDM1 with atherosclerosis was further underpinned by analysis of an independent human CEA plaque cohort (BiKE [21]), showing almost ten fold higher expression of PRDM1 (P < 0.0001) in atherosclerotic (n = 127) than in control non-atherosclerotic artery tissue (n = 10) (Fig. 5g). This evidence concerns the gene PRDM1 and atherosclerosis.