In contrast to many ADAMs (including ADAM-2, −7, −18, −20, −21, −29, and −30) that are expressed primarily in the testis, where they play different roles in spermatogenesis and sperm function (reviewed in [141]), ADAM15 is abundantly expressed in vascular cells, including smooth muscle and endothelial cells, and has been involved in vascular pathologies, including atherosclerosis and pathological neovascularization [162–164]. This evidence concerns the gene ADAM15 and atherosclerosis.