Interestingly, CDH5, CDH17, and L1CAM share their involvement in several metastatic cancers [102, 103, 114, 242, 243], which could be related to the pairwise sequence alignment found near the RGD motif for the combinations CDH17/L1CAM and CDH17/CDH5 (its second RGD motif). Here, L1CAM is linked to metastatic malignant neoplasm.