ENG and hereditary hemorrhagic telangiectasia: Thus, L1CAM is associated with hydrocephalus, congenital X-linked (HYCX), Hirschsprung disease, and MASA (Mental retardation, Aphasia, Shuffling gait and Adducted thumbs) syndrome; endoglin is involved in hereditary hemorrhagic telangiectasia and preeclampsia; and CADH5, CADH6, and CADH17 are linked to cancer progression and metastasis, just to name a few.