The objective of this study is to determine whether METTL3 facilitates the expression of miR-34a-5p through m6A methylation of pri-miR-34a, and whether this miRNA, by targeting Wnt1, suppresses the Wnt/β-catenin signaling pathway, thereby enhancing TGVS activation and contributing to migraine pathogenesis. Here, WNT1 is linked to migraine disorder.