Our findings elucidate a novel epigenetic cascade in migraine pathogenesis: METTL3-mediated m6A modification facilitates DGCR8-dependent processing of pri-miR-34a into mature miR-34a-5p, which subsequently exacerbates the activation of TGVS through the targeted suppression of the Wnt1/β-catenin signaling pathway (Fig. 9). Here, METTL3 is linked to migraine disorder.