TGFB1 and hypertensive disorder: Given the central role of TGFβ in CF activation, myofibroblast differentiation and fibrosis6,56,57, and its modulation by T8Ab in both MI and hypertension models (Figs. 4f and 5f and Supplementary Figs. 9b, 10 and 13) we next investigated the impact of ANTXR1 on TGFβ signaling.