PROM1 and cancer: CD133 is a crucial glycoprotein with pentaspan-transmembrane structure involved in identification of diverse kinds of normal stem cells and various cancer stem-like cells (CSC) (Li 2013; Sansone et al, 2016; Mancebo et al, 2017; Zhou et al, 2021; Yamashita et al, 2022; Ahn et al, 2024), including colorectal cancer (CRC) (Singh et al, 2004; Ricci-Vitiani et al, 2007; Calvanese et al, 2022), liver cancer (Stephanie 2013) and lung cancer (Wu et al, 2014).