Elevated CD133 expression was observed in several cancers in the TCGA dataset, including colon adenocarcinoma (COAD), cholangiocarcinoma (CHOL), pancreatic adenocarcinoma (PAAD), rectum adenocarcinoma (READ), and stomach adenocarcinoma (STAD) (Fig. 1A). The gene discussed is PROM1; the disease is rectum adenocarcinoma.