Infection activates DRH-1, the ortholog of the DEAD/H-box Helicase and cytosolic pattern recognition receptor RIG-I to limit viral infection and pathogenesis (Ashe et al, 2013; Batachari et al, 2024; Coffman et al, 2017; Gammon et al, 2017; Guo et al, 2013; Lu et al, 2009; Sowa et al, 2020). The gene discussed is RIGI; the disease is viral infectious disease.