The aim of this study was to assess the impact of short-term non-steroidal androgen blockade therapy (NSAA) on lesion PSMA expression and cellularity using dynamic [68Ga]Ga-PSMA-11PET and diffusion-weighted magnetic resonance imaging (MR) for simultaneous estimation of binding potential (BPND) and apparent diffusion coefficient (ADC) in hormone-naïve patients with high-risk PCa without bone metastases. This evidence concerns the gene FOLH1 and posterior cortical atrophy.