FOLH1 and neoplasm: Although the negative association between ΔADC% and ΔBPND% in the extended LME model did not reach conventional significance (p = 0.064), our results underscore the importance of accounting for tumour heterogeneity and adaptive mechanisms when interpreting imaging changes following short-term ADT, as PSMA-PET imaging and MR-diffusion metrics capture different underlying histopathological and cellular responses.