rs138707495, a rare (MAF: European=0.009, Mixed=0.005) variant located in the 3’ UTR of GDF7 (OR (95%CI) = 3.06 (2.07, 4.53), pmeta = 2.33 × 10−8), rs77750788 at 11q25 near IGSF9B (OR (95%CI) = 2.07 (1.61, 2.68), pmeta = 2.03 × 10−8) and rs181194133 an intronic variant in OPCML (OR (95%CI) = 3.44 (2.24, 5.31), pmeta = 2.09 × 08−08) were all associated with increased risk of HPC in the cross-ancestral meta-analysis. The gene discussed is IGSF9B; the disease is hereditary chronic pancreatitis.