While the most impactful variants defined by our ranking system were both in ATM (p.Arg3047X and p.Arg2832Cys), overall the most impacted known PCa GT gene was BRCA2. Conversely, no PPVs/POVs were identified in BRCA1, HOXB13, CDK12, MLH1, MSH2, or BRIP1. Here, BRIP1 is linked to posterior cortical atrophy.