Additional unknown candidate genes outranking FANCA include known DDR genes ERCC2, RECQL4, CLSPN, MSH3, FANCD2, HERC2, TRRAP and CREBBP (PSLP driven), DDR-relevant genes ROS1, ASPM, KMT2D, ERBB3, PRDM2, FGFR4, KMT2C, LEF1 and PER1, and the PCa germline associated oncogene RET (Supplementary Data 10). The gene discussed is PRDM2; the disease is posterior cortical atrophy.