Notably, PSLF-POVs impacting known PCa GT panel genes ATM (p.Asp44Gly) and PMS2 (p.Leu729X) presented in both our SACs and EACs (MAFs range 0.0204 to 0.0306) as did nine of the remaining PSLF-POVs and as such were removed from further analyses (Supplementary Data 8). The gene discussed is PMS2; the disease is posterior cortical atrophy.