Focusing on known PCa GT genes (24 rare PPV/POVs in 11 genes), we observe a study prevalence of 11.06% (24/217), with a single PPCG patient (PPCG0019, 57% African genetic ancestry) presenting with three candidate variants in RAD54L, PMS2 and FANCA each, with the latter variant showing a 2nd hit and LOH in the patient-matched tumour. Here, PMS2 is linked to posterior cortical atrophy.