While the BRCA2-associated signature SBS3 was found to be enriched in a single SAPCS patient with no DDR/known PCa-associated PPV/POV germline variant, no enrichment was observed for signatures with associated DDR-related aetiologies, including SBS6, SBS15, SBS21, SBS26 and SBS44, while the MSH6 POV carrier did not present with the gene-associated copy-number (CN)25 tumour enrichment. Here, BRCA2 is linked to neoplasm.