When combining rare and PSLF variants, POLQ outranks PREX2, while POLG ranking approaches that of ATM. In contrast to the DDR DNA poloymerase genes, POLE, POLQ and POLG, and DDR-relevant genes, PREX2 and LRP1B, FAT1 is a known PCa tumour suppressor40. The gene discussed is POLE; the disease is posterior cortical atrophy.