Additionally, while candidate PPV/POVs in known GT genes, including BRCA2 (p.Trp31Arg) and FANCA (p.Arg504Gly) showed tumour associated DDR-like mutational signature enrichment, the 28 PPV/POVs in unknown GT-candidates showing DDR-like mutational enrichment provides further merit for consideration. The gene discussed is BRCA2; the disease is neoplasm.