In agreement with previous studies on RAB32 and LRMDA, we observed a decrease in pigmentation in RAB32 CRISPR/Cas9 knock-out human melanoma MNT1 cells (Fig. 4F–H), as well as in a previously characterised LRMDA knock-out MNT1 cell line (Fig. 4I, J)17. Here, LRMDA is linked to melanoma.