LRMDA and obesity due to melanocortin 4 receptor deficiency: Similarly, LRMDA has been implicated in a variety of disease conditions that appear to be un-related to melanosome biogenesis: a SNP (rs10824307) near LRMDA is associated with mild-obesity-related diabetes68, and as highlighted previously17, at least two OCA7 patients harbouring LRMDA mutations have recurrent infections69.