NPY and peripheral neuropathy: Skin tissue is highly innervated, and it has been proven that various neuropeptides participate in wound repair, such as calcitonin gene-related peptide (CGRP), neuropeptide Y.21 However, peripheral neuropathy is a common complication in diabetic patients, making nerve recovery an important indicator for evaluating diabetic wound repair.22,23 The results of immunofluorescence staining showed that there were more CGRP+ sensory nerves distributed around the hair follicles and epidermal areas at the edge of the wound in the BD group.