Previous study showed that p53‐binding protein (53BP1) mediates phosphorylation of ACLY, enhances ACLY activity, and further upregulates stem‐loop binding protein (SLBP) promoter acetylation, thereby regulating the DNA double‐strand break (DSB) repair pathway and maintaining genomic integrity.[12] Acetylation of ACLY‐lysine (K) 540/546/554 sites competitively inhibits ubiquitination at these lysine sites, promoting lipid synthesis and cell proliferation in tumor cells.[13] However, the functions of ACLY epigenetic modifications in cancer chemoresistance are still unknown. The gene discussed is ACLY; the disease is cancer.