The Tumor microenvironment (TME) of ACC is typically characterized by an “immune desert” phenotype, with markedly reduced infiltration of effector immune cells such as CD8+ T cells and dendritic cells compared to immunologically “hot” tumors like melanoma and lung cancer, which hinders the initiation and effect of anti-tumor immune response [12, 13]. The gene discussed is CD8A; the disease is neoplasm.