For example, in hypothalamus of aged mice, Solute carrier family 7 member 14 (SLC7A14) expression in decreased, and overexpression of SLC7A14 in hypothalamic POMC neurons alleviated impaired lipolysis in white adipose tissue of aged mice, thereby alleviating aged-dependent obesity [11]. This evidence concerns the gene POMC and obesity due to melanocortin 4 receptor deficiency.