In adipose tissue, ROS–FoxO1 signaling suppresses peroxisome proliferator-activated receptor γ (PPARγ) and promotes lipolysis (via adipose triglyceride lipase (ATGL)/hormone-sensitive lipase (HSL)) during fasting, but under overnutrition drives inflammation and insulin resistance via NF-κB/JNK [52, 53]. Here, PNPLA2 is linked to Insulin resistance.