When we tested HLA alleles for association, the most significant association with risk in AFR and AMR ancestry was with HLA-DQA1*03:01 (ORAFR=5.45, pAFR=9.28 × 10−116; ORAMR=2.91, pAMR=2.44 × 10−21), while HLA-DQB1*03:02 was most strongly associated with type 1 diabetes risk in EUR and FIN ancestry (OREUR=5.33, pEUR=5.08 × 10−1145; ORFIN=3.91, pFIN=8.76 × 10−76). The gene discussed is HLA-DQB1; the disease is type 1 diabetes mellitus.