In their study on the effects of exendin-4, a GLP-1 analog, on gastric ulcer healing in a gastric ulcer model of diabetic rats, Chen et al.3 reported that the IL-1β and IL-6 levels increased, the IL-10 levels decreased in the gastric tissue of diabetic rats, and the IL-1β, IL-6, and IL-10 levels approached control group levels with the exendin-4 treatment3. This evidence concerns the gene GLP1R and gastric ulcer.