SH3GL2 and epilepsy: Moreover, in a chemical kindling mouse model of epilepsy, in which mice are chronically induced with the GABAAR antagonist pentylenetetrazole (PTZ) (Dhir, 2012), endophilin A1 was also upregulated in the hippocampus and adjacent temporal cortex, and silencing its expression in the hippocampal CA3 region reduced PTZ-induced seizure susceptibility and severity (Yu et al., 2018b).