On study (during C1), CRS was associated with higher induction of IL‐6 (significant in QW and Q2W cohorts, Figure 5b) and a trend for higher induction of IFNγ, TNFα, and soluble IL‐2Rα; again, higher induction was observed with grade ≥ 2 CRS. The gene discussed is TNF; the disease is congenital rubella syndrome.