Fig. 1B and C show the effect of the choice of promoter definition on differential promoter methylation for the genes FLT1, which encodes the vascular endothelial growth factor receptor 1 and which has been reported as hypermethylated in prostate cancer [45], and POLR2H, encoding one of the RNA polymerase subunits. The gene discussed is POLR2H; the disease is prostate cancer.