This study aimed to evaluate the extracellular matrix of pancreatic ductal adenocarcinoma (PDAC) using the extracellular volume fraction (fECV) derived from enhanced CT images, integrating fECV with α‐SMA‐positive cancer‐associated fibroblasts (CAFs) and FAP‐positive CAFs to investigate their relationship with clinicopathological characteristics and prognosis of patients with PDAC. The gene discussed is ACTA1; the disease is pancreatic ductal adenocarcinoma.