As illustrated in the forest plot (Figure 6), the results of multivariable Cox regression analysis revealed that lymph node metastasis (p = 0.025), distant liver metastasis (p = 0.031), high expression of α‐SMA (p = 0.005), high expression of FAP (p < 0.001), and lower fECV (p = 0.015) were independent risk factors for patients undergoing postoperative chemotherapy for PDAC. The gene discussed is ACTA1; the disease is metastatic malignant neoplasm in the lymph nodes.