AKT1 and neoplasm: Furthermore, PTEN acts to suppress the PI3 K/AKT pathway [129], however, NO inhibits NF-κB, Snail, and YY1, resulting in PTEN downregulation and subsequent suppression of PTEN-mediated PI3 K/AKT signaling, thereby influencing proliferation and apoptosis resistance pathways in tumor cells [129,130].