Treatment of cells with high iNOS expression – such as triple-negative breast cancer (TNBC) – with 1400W (a highly selective iNOS inhibitor), L-NAME (a relatively selective eNOS inhibitor), or L-NMMA (a pan-NOS inhibitor) resulted in reduced cell proliferation, migration, and mammosphere formation [191]. The gene discussed is NOS2; the disease is triple-negative breast carcinoma.