SHBG and neoplasm: Elevated TyG index promotes urogenital system cancers through similar metabolic‐inflammatory mechanisms as digestive cancers, with additional endocrine effects: (1) Hormonal dysregulation: Insulin resistance increases androgens (e.g., in PCOS) [42] and bioavailable estrogen (via sex hormone‐binding globulin [SHBG] suppression) and creates a pro‐tumor environment for endometrial/ovarian cancers [43].