ALK and necrosis: In addition, the presence of epidermal growth factor receptor (EGFR) mutation does not affect the incidence of brain radiation necrosis [23], but anaplastic lymphoma kinase (ALK) rearrangements in NSCLC further amplifies the risk, with a 12-month cumulative incidence at 18 % compared to 4 %–8 % in other genetic profiles within lung cancer [24].