LF polysaccharides can also reduce the levels of TNF‐α and IL‐6 in the serum of diabetic nephropathy rats and increase the level of IL‐10 by inhibiting the TLR4/Myd88 signaling pathway, thereby reducing the degree of vacuolar degeneration and inflammatory infiltration of glomerular epithelial cells (Qu, Bian, et al. 2020). Here, IL6 is linked to diabetic kidney disease.