LB extract can inhibit the growth of subcutaneous tumors in Lewis lung cancer‐bearing mice and suppress the EMT of lung cancer cells by regulating the PI3K/AKT pathway, blocking the binding of PD‐L1 and PD‐1, downregulating the expression of the stromal markers N‐cadherin and vimentin, and increasing the expression of the epithelial marker E‐cadherin, thereby reducing the invasion and migration ability of the lung cancer cell lines A549 and H1299, restoring immune cell function, and promoting the killing of tumor cells by T cells (Yin 2021). The gene discussed is CDH2; the disease is lung cancer.