CD274 and neoplasm: They can block tumor cells in the G0/G1, S, and G2/M phases by regulating the MAP3K3, NF‐κB, MMTV, PyMT, PD1/PD‐L1, and P53 signaling pathways; induce cancer apoptosis; inhibit tumor cell proliferation, tumor interstitial blood vessel formation, invasion, and metastasis; improve immune escape; reduce chemical drug resistance; improve treatment sensitivity; and play an inhibitory role in digestive and reproductive system tumors (Wang et al. 2018; Jiang and Li 2022; Shan et al. 2010).