LF saponins inhibit the proliferation, invasion, and metastasis of breast, lung, and nasopharyngeal cancer cells and induce their apoptosis by regulating the interaction between adipocytes and breast cancer cells (He et al. 2019), targeting nonmuscle myosin IIA (Wei et al. 2016), and inhibiting the expression of the Suv39H1 and Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathways (Hu et al. 2021). This evidence concerns the gene STAT3 and breast cancer.