GDF5 and brachydactyly: For instance, mutations in GDF5, BMPR1B, IHH, and ROR2 disrupt the TGF‐β signaling cascade essential for endochondral ossification, contributing to types A1, A2, B, and C.[4, 16] Insights from developmental biology, including the role of BMP/p‐SMAD signaling in phalangeal precursor cells, explain digit‐specific variations like the preservation of the ring finger in certain types of brachydactyly.[4] These findings highlight the intricate interplay between genetic, molecular, and embryological factors in shaping limb development.