GDF5 and brachydactyly: Brachydactyly is genetically linked to mutations in developmental and glycosyltransferase‐related genes (e.g., HOXD13, GDF5, CHSY1) affecting bone morphogenesis and glycosaminoglycan biosynthesis pathways.[17] Brachydactyly arises from disruptions in genes critical for limb patterning and development during embryogenesis, including HOXD13, which regulates the spatial and temporal expression of limb structures.