HOXD13 and brachydactyly: Brachydactyly type D (BDD) is characterized by a shortened distal thumb phalanx and broad toes, with complete penetrance in females and incomplete penetrance in males.[20] Bilateral expression occurs in ≈75% of affected individuals.[20] A mutation in HOXD13 has been implicated in BDD.[18] Grebe, Hunter‐Thompson, and Du Pan acromesomelic dysplasias are severe autosomal recessive limb disorders caused by homozygous GDF5 mutations.[20] Grebe dysplasia exhibits profound limb shortening, absent ossification of phalanges, and rudimentary digits resembling toes.