INS and Hypoglycemia: Insulin injections delivered to the peripheral circulation are a key contributor to hypoglycemia and associated cardiac autonomic neuropathy.[8] Targeting insulin to the liver via oral delivery reduces hypoglycemia.[9] Frequent insulin injections contribute to treatment non‐adherence, leading to poor health outcomes.[10] Cost‐related insulin rationing in developed countries has serious health consequences.[11] Therefore, there is an urgent need to develop non‐invasive methods of oral or topical drug delivery.