REN and migraine disorder: Other hypothesized mechanisms of these medications in migraine prophylaxis include: reduction in the hyperactivity of renin-angiotensin-aldosterone, catecholaminergic and adrenergic systems; inhibition of excessive vasoconstriction due to 5-HT release; inhibition of neurogenic inflammation; regulation of central neuronal activity; membrane stabilization; and modulation of serotonin (7).