In our study, these three ubiquitination-related genes, namely ANAPC11, UCHL1, and USP41, were identified as the key genes that might be involved in the pathogenesis of MMD, and these genes were closely associated with multiple signaling pathways of protein modification, autoimmune, immune response, neutrophil extracellular trap formation, base excision repair, Hippo signaling pathway, and NF − kappa B signaling pathway. The gene discussed is USP41P; the disease is multiminicore myopathy.