In this study, we fabricated a biocompatible oral peptide delivery nanosystem, M@P@T (M = MOF-808, P = TRP, T = Transferrin), for effective osteoporosis therapy (Scheme 1), utilizing acid-resistant Zr-based MOF (MOF-808) NPs to encapsulate TRP and further coating it with the targeting protein transferrin (Tf). This evidence concerns the gene TF and osteoporosis.