A heatmap was used to demonstrate the top 10 upregulated genes, namely, CD34, SPINK2, SMYD3, DEPTOR, ATF3, HOXA5, HOXA10, ATP8B4, CLEC11A, and FLT3, whereas the expressions of IL18RAP, CYP4F3, FPR2, CD14, PLBD1, C5AR1, TGFB1, LEF1, IL7R, and HBB were downregulated in AML (Figure 2B). The gene discussed is ATP8B4; the disease is acute myeloid leukemia.