It was suggested that AML exhibited increased infiltration by immunosuppressive cells (Tregs, M2-like macrophages, plasma cells, and resting mast cells), while the fraction of pro-inflammatory cells (M1-like macrophages and activated CD4+ memory T cells) and naïve T/B cells were significantly reduced (Figure 3C), which were characterized by the immunosuppressive microenvironment. This evidence concerns the gene CD4 and acute myeloid leukemia.