A heatmap was used to demonstrate the top 10 upregulated genes, namely, CD34, SPINK2, SMYD3, DEPTOR, ATF3, HOXA5, HOXA10, ATP8B4, CLEC11A, and FLT3, whereas the expressions of IL18RAP, CYP4F3, FPR2, CD14, PLBD1, C5AR1, TGFB1, LEF1, IL7R, and HBB were downregulated in AML (Figure 2B). This evidence concerns the gene SMYD3 and acute myeloid leukemia.