The radical resection will aggravate postoperative malnutrition due to significant trauma, long time, and postoperative stress, thus affecting the function of the body’s immune system, stimulating the production of TNF-α, IL-6, arachidonic acids, nitric oxide, and other inflammatory mediators in liver Kupffer cells, causing systemic inflammation and even biliary sepsis (16). Here, IL6 is linked to malnutrition.