Complex-1, which consists of a platinum (IV) core conjugated with Salvigenin ligand, significantly downregulates cancer cell stemness by inhibiting Rap1b expression and blocking its mediated integrin signaling and Wnt/β-catenin/TCF pathway; and enhances the platinum accumulation in cisplatin-resistant cells (TE6/cDDP) and inhibits the DNA damage repair ability (Fang et al., 2019). This evidence concerns the gene RAP1B and cancer.