HSF1 and cancer: Cantharidin (CTD), a terpenoid isolated from blister beetles and used in traditional Chinese medicine for the treatment of a variety of diseases and cancers (Deng et al., 2013), has been shown to be an inhibitor of protein phosphatase 2A (PP2A) and heat shock transcription factor 1 (HSF-1), both of which are potential anticancer targets (Kim et al., 2013; Li W. et al., 2017).