The downstream inflammatory factor MMP-9, a product of the Wnt/β-catenin signaling pathway, contributes to the degradation of collagen and other matrix proteins in damaged tissues (Xiao et al., 2022), Abnormal expression and activation of MMP-9 can disrupt normal tissue integrity and accelerate ulcer formation (Chang and Nguyen, 2021). The gene discussed is MMP9; the disease is ulcer disease.