Besides, histone-modifiers of the KMT2 (histone-lysine N-methyltransferase 2) family are also frequently associated with the development of cancer, in particular KMT2A/MML1 (mixed lineage leukemia 1), which dearrangement leads to an oncogenic fusion protein in acute lymphoblastic leukemia (Ford and Dingwall, 2015). This evidence concerns the gene KMT2A and acute lymphoblastic leukemia.