TEAEs (66%)Fatigue (6%)ALT ↑ (16%)AST ↑ (16%)Anemia (2%)Confusional state (2%)Hyperglycemia (2%)Hyponatremia (2%)Hypotension (2%)Pruritus (2%)Urinary tract infection (2%)irAEs (28%)Pruritis (4%)Colitis (8%)ALT ↑ (16%)AST ↑ (16%). The gene discussed is GPT; the disease is anemia (phenotype).