TRAEs (95.7%)Fatigue (54.3%)Nausea (57.1%)Vomiting (32.9%)Diarrhea (41.4%)ALT ↑ (22.9%)AST ↑ (20%)Hematological irAEsAnaemia (40%)Thrombocytopenia (22.9%)Neutropenia (11.4%)Leukopenia (20%). The gene discussed is GPT; the disease is Decreased total leukocyte count.