TRAEs (60%)Fatigue (34%)Nausea (21%)Vomiting (10%)Diarrhea (18%)Pruritis (23%)ALT ↑ (7%)Arthralgia (22%)AST ↑ (8%)Rash (34%)irAEsPneumonitis (2%)Colitis (2%). The gene discussed is GPT; the disease is Arthralgia.