Several lines of evidence have proved that deficiency of brain pericytes led to BBB permeability (Armulik et al., 2010), vascular damage (Bell et al., 2010; Winkler et al., 2010), Tau protein hyperphosphorylation (Sagare et al., 2013), Aβ deposition (Sengillo et al., 2013), and white matter functional deficits (Montagne et al., 2018), which inevitably accelerated the process of AD. Here, MAPT is linked to Alzheimer disease.