Wang et al. (2021) showed that in 3xTg-AD mice (AD model) fed a high-fat diet, atherosclerosis induces the formation of platelet-associated fibrillar Aβ aggregates; increases CAA burden, tau pathology, and neuronal loss; impairs cerebral blood flow, and exacerbates cognitive deficits. The gene discussed is MAPT; the disease is Alzheimer disease.