Thus, our present cancer model study using syngeneic cancer cell transplantation unequivocally demonstrates that NRF2 hyperactivation in cancer cells provokes low-level immune cell infiltration to tumors or immune evasion through activating NRF2-dependent immune-suppressive genes, and this process contributes to the establishment of the malignancy of NRF2-activated tumors. This evidence concerns the gene NFE2L2 and cancer.