To investigate the influences of the NRF2 activation in 3LL cancer cells on the tumor microenvironment, we challenged transplantation experiments of KEAP1-KO and wild type (WT) 3LL cell lines, taking advantage of the syngeneic immunocompetent nature of 3LL cells toward albino C57BL/6 mouse strain. Here, NFE2L2 is linked to neoplasm.