,47 Notably, hyperphosphorylation of the PI3K/Akt/mTOR pathway was observed in the gastric cancer cell lines MKN45 and MKN7, consistent with reports that these cell lines are sensitive to inhibitors targeting this pathway from the CancerRxGene database (www.cancerrxgene.org/celllines). Here, AKT1 is linked to gastric cancer.