ART4 and hepatocellular carcinoma: Distinct lineage-specific patterns emerged: epithelial-derived lines (e.g., HCC-827, NCI-H460, OVISE) showed higher overall glycoprotein abundance, particularly in cadherin-binding and ECM-associated proteins, whereas hematologic lines (e.g., CCRF-CEM, Pfeiffer, Ramos) displayed lower glycoprotein detection, reflecting differences in surface glycan presentation and enrichment efficiency.